925684-98-6

Upstream product

• 75-44-5 phosgene 
• 145070-49-1 (rac)-1-(4-bromophenyl)-2-hydroxypropan-1-one 
• 481632-29-5 1-(4-bromophenyl)-1-oxopropan-2-yl formate 
• 38786-67-3 2-bromo-1-(4-bromophenyl)propan-1-one 
• 102-09-0 bis(phenyl) carbonate 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 925684-99-7 ethyl (diethylphosphonomethyl)-(4-(5-methyl-2-oxo-1,3-dioxol-4-yl)phenyl)phosphinate 
• 925685-00-3 ethyl (diethylphosphonomethyl)-(4-(5-(bromomethyl)-2-oxo-1,3-dioxol-4-yl)phenyl)phosphinate 
• 925685-01-4 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(O-ethyl(diethylphosphonomethyl)phosphonoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 
• 1072452-91-5 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-4-((2-oxo-5-(4-(phosphonomethylphosphinoyl)phenyl)-1,3-dioxol-4-yl)methyl)piperazin-1-yl)-4-oxoquinoline-3-carboxylic acid monotriethylammonium salt 

Relevant academic research and scientific papers

Organocatalytic Synthesis of Substituted Vinylene Carbonates

The organocatalytic synthesis of substituted vinylene carbonates from benzoins and acyloins was studied using diphenyl carbonate as a carbonyl source. A range of N-Heterocyclic Carbene (NHC) precursors were screened and it was found that imidazolium salts were the most active for this transformation. The reaction occurs at 90 °C under solvent-free conditions. A wide range of substituted vinylene carbonates (symmetrical and unsymmetrical, aromatic or aliphatic), including some derived from natural products, were prepared with 20–99% isolated yields (24 examples). The reaction was also developed using thermomorphic polyethylene-supported organocatalysts as recoverable and recyclable species. The use of such species facilitates the workup and allows the synthesis of vinylene carbonates on the preparative scale (>30 g after 5 runs). (Figure presented.).

Phosphonated Fluoroquinolones, Antibacterial Analogs Thereof, and Methods for the Prevention and Treatment of Bone and Joint Infections

The present invention relates to phosphonated fluoroquinolones, antibacterial analogs thereof, and methods of using such compounds. These compounds are useful as antibiotics for prevention and/or the treatment of bone and joint infections, especially for the prevention and/or treatment of osteomyelitis.

Linking bisphosphonates to the free amino groups in fluoroquinolones: Preparation of osteotropic prodrugs for the prevention of osteomyelitis

Osteomyelitis is an infection located in bone and a notoriously difficult disease to manage, requiring frequent and heavy doses of systemically administered antibiotics. Targeting antibiotics to the bone after systemic administration may provide both grea