4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

Base Information

Chemical Name:4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile
CAS No.:245425-31-4
Molecular Formula:C₂₃H₁₈N₂O₂
Molecular Weight:354.408
Hs Code.:

Synonyms:4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

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Chemical Property of 4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

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Technology Process of 4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

There total 7 articles about 4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 544-92-3
copper(I) cyanide

: 245425-30-3
3-[2-(benzyloxy)-5-bromophenyl]-3,4-dihydro-2(1H)-quinolinone

: 245425-31-4
4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

Guidance literature:: In N,N-dimethyl-formamide; at 160 ℃; for 12h;
DOI:10.1021/jm0497491

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 245425-31-4
4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: Ac₂O; Et₃N / 0.25 h / 140 °C

2: 49 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 5 h

3: 85 percent / Br₂ / CS₂; CH₂Cl₂ / 2 h

4: 68 percent / Cs₂CO₃ / dimethylformamide / 16 h / 20 °C

5: 45 percent / dimethylformamide / 12 h / 160 °C

With hydrogen; bromine; acetic anhydride; caesium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; carbon disulfide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497491

Reference yield:

: 614-75-5
2-Hydroxyphenylacetic acid

: 245425-31-4
4-(benzyloxy)-3-(2-oxo-1,2,3,4-tetrahydro-3-quinolinyl)benzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: Ac₂O; Et₃N / 0.25 h / 140 °C

2: 49 percent / H₂ / Pd/C / methanol; tetrahydrofuran / 5 h

3: 85 percent / Br₂ / CS₂; CH₂Cl₂ / 2 h

4: 68 percent / Cs₂CO₃ / dimethylformamide / 16 h / 20 °C

5: 45 percent / dimethylformamide / 12 h / 160 °C

With hydrogen; bromine; acetic anhydride; caesium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; carbon disulfide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0497491