1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine

Base Information

• Chemical Name: 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine
• CAS No.: 1316754-21-8
• Molecular Formula: C₂₄H₃₀N₆OS
• Molecular Weight: 452.597

Synonyms:1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine

Chemical Property of 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine

Chemical Property:

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Technology Process of 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine

There total 7 articles about 1-(1-benzyl-2-methylthio-2-[⁽¹⁴⁾C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-benzyl-2-methylthioimidazole-5-carboxylic acid-2-[(14)C] (1316754-25-2) + [3-(1-methylethylamino)-2-pyridinyl]piperazine (147539-21-7) → 1-(1-benzyl-2-methylthio-2-[(14)C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine (1316754-21-8)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/jlcr.1880

Reference yield:

1-benzyl-5-hydroxymethyl-2-methylthioimidazole-2-[(14)C] (1316754-22-9) → 1-(1-benzyl-2-methylthio-2-[(14)C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine (1316754-21-8)

Guidance literature:

Multi-step reaction with 3 steps

1: manganese(IV) oxide / chloroform / Reflux

2: silver nitrate; sodium hydroxide / water / 20 °C

3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C

With manganese(IV) oxide; silver nitrate; 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; chloroform; water;

DOI:10.1002/jlcr.1880

Reference yield:

1-[1,1-dimethylethoxycarbonyl]-4-[3-amino-2-pyridinyl]piperazine (111669-25-1) → 1-(1-benzyl-2-methylthio-2-[(14)C]-5-imidazoyl)-4-[3-(isopropylamino)-2-pyridyl]piperazine (1316754-21-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride

2: trifluoroacetic acid

3: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0 - 20 °C

With sodium cyanoborohydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran;

DOI:10.1002/jlcr.1880

upstream raw materials:

1-benzyl-2-methylthio-5-formylimidazole-2-[⁽¹⁴⁾C]

1-benzyl-2-methylthioimidazole-5-carboxylic acid-2-[⁽¹⁴⁾C]

[3-(1-methylethylamino)-2-pyridinyl]piperazine

1-benzyl-5-hydroxymethyl-2-methylthioimidazole-2-[⁽¹⁴⁾C]

Downstream raw materials:

2-(4-((1-benzyl-2-(methylthio)-2-[⁽¹⁴⁾C]-imidazol-5-yl)methyl)-piperazin-1-yl)-N-isopropylpyridin-3-amine

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