[(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile

Base Information

• Chemical Name: [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile
• CAS No.: 312519-40-7
• Molecular Formula: C₁₅H₁₄N₄O₂
• Molecular Weight: 282.302
• Mol file: 312519-40-7.mol

Synonyms:[(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile

Chemical Property of [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile

There total 2 articles about [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxy-benzaldehyde (123-11-5) + 3-methyl-2-pyrazoline-5-one (108-26-9) + malononitrile (109-77-3) → [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile (312519-40-7)

Guidance literature:

With ethanol; sodium acetate; at 20 ℃; for 1h; Time; Green chemistry;

DOI:10.1016/j.crci.2013.03.003

Reference yield: 88.0%

ethyl acetoacetate (141-97-9) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → [(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile (312519-40-7)

Guidance literature:

With zinc ferrite; hydrazine hydrate; In neat (no solvent); at 20 ℃; for 0.2h; Green chemistry;

DOI:10.3184/174751915X14358475706316

Reference yield: 68.0%

[(5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-methoxyphenyl)methyl]malononitrile (312519-40-7) → 2-(4-methoxyphenyl)-4-methyl-7-oxo-5,6-diazaspiro[2.4]hept-4-ene-1,1-dicarbonitrile

Guidance literature:

With bromine; sodium ethanolate; In ethanol; at 20 ℃; for 3h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1016/j.mencom.2016.01.008

upstream raw materials:

4-methoxy-benzaldehyde

3-methyl-2-pyrazoline-5-one

malononitrile

ethyl acetoacetate