(R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Base Information

Chemical Name:(R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile
CAS No.:1621222-42-1
Molecular Formula:C₂₅H₂₁ClF₃N₇
Molecular Weight:511.937
Hs Code.:

Synonyms:(R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

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Chemical Property of (R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

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Technology Process of (R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

There total 5 articles about (R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621222-21-6
6-[[(1R)-1-cyclobutylethyl]amino]-7-[[4-(trifluoromethyl)phenyl]methyl]-7H-purine-2-carbonitrile

: 22918-01-0
2-bromo-4-chloropyridine

: 1621222-42-1
(R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Guidance literature:: With palladium diacetate; cesium fluoride; catacxium A; Trimethylacetic acid; In 1,4-dioxane; at 130 ℃; for 48h; Inert atmosphere;

Reference yield:

: 402-49-3
4-bromomethyltrifluoromethylbenzene

: 1621222-42-1
(R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate / tetrahydrofuran / Inert atmosphere; Reflux

2: triethylamine / isopropyl alcohol / 50 °C

3: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

4: catacxium A; palladium diacetate; cesium fluoride; Trimethylacetic acid / 1,4-dioxane / 48 h / 130 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; triethylamine; cesium fluoride; sodium t-butanolate; catacxium A; XPhos; Trimethylacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; isopropyl alcohol;

Reference yield:

: 5451-40-1
2,6-dichloro-7H-purine

: 1621222-42-1
(R)-8-(4-chloropyridin-2-yl)-6-((1-cyclobutylethyl)amino)-7-(4-(trifluoromethyl)benzyl)-7H-purine-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate / tetrahydrofuran / Inert atmosphere; Reflux

2: triethylamine / isopropyl alcohol / 50 °C

3: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 120 °C / Inert atmosphere

4: catacxium A; palladium diacetate; cesium fluoride; Trimethylacetic acid / 1,4-dioxane / 48 h / 130 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; triethylamine; cesium fluoride; sodium t-butanolate; catacxium A; XPhos; Trimethylacetic acid; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; isopropyl alcohol;