N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide

Base Information

• Chemical Name: N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide
• CAS No.: 1420180-98-8
• Molecular Formula: C₂₃H₂₅NO₆S
• Molecular Weight: 443.521
• Mol file: 1420180-98-8.mol

Synonyms:N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide

Chemical Property of N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide

There total 4 articles about N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-butyl-3-[4-(3,3-diethoxypropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide (1420180-99-9) → N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide (1420180-98-8)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; water; at 50 ℃; for 2h;

Reference yield:

(5-amino-2-butyl-benzofuran-3-yl)[4'-(3,3-diethoxypropoxy)phenyl]methanone (1420181-00-5) → N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide (1420180-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 2.5 h / 30 - 35 °C

2: sulfuric acid / tetrahydrofuran; water / 2 h / 50 °C

With pyridine; sulfuric acid; In tetrahydrofuran; dichloromethane; water;

Reference yield:

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone (1420181-01-6) → N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide (1420180-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 50 °C / 7500.75 Torr

2: pyridine / dichloromethane / 2.5 h / 30 - 35 °C

3: sulfuric acid / tetrahydrofuran; water / 2 h / 50 °C

With pyridine; sulfuric acid; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; dichloromethane; water;

upstream raw materials:

N-(2-butyl-3-[4-(3,3-diethoxypropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide

(5-amino-2-butyl-benzofuran-3-yl)[4'-(3,3-diethoxypropoxy)phenyl]methanone

(2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone

2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran

Downstream raw materials:

dronedarone