Platinum,amminedichloro(cyclohexanamine)dihydroxy-, (OC-6-12)-

Base Information

• Chemical Name: Platinum,amminedichloro(cyclohexanamine)dihydroxy-, (OC-6-12)-
• CAS No.: 146924-11-0
• Molecular Formula: C₆H₁₈Cl₂N₂O₂Pt
• Molecular Weight: 416.207
• Mol file: 146924-11-0.mol

Synonyms:JM 335

Chemical Property of Platinum,amminedichloro(cyclohexanamine)dihydroxy-, (OC-6-12)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Platinum,amminedichloro(cyclohexanamine)dihydroxy-, (OC-6-12)-

There total 7 articles about Platinum,amminedichloro(cyclohexanamine)dihydroxy-, (OC-6-12)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

cis-dichloro-trans-ammonia(cyclohexylamine)platinum (159701-67-4,99038-38-7,174691-91-9) → (OC-6-43)-amminedichloro(cyclohexanamine)dihydroxyplatinum(IV) (124721-03-5,1313200-52-0,146924-11-0)

Guidance literature:

With water; dihydrogen peroxide; In water; addn. of 5 equiv. 30% H2O2 to suspn. of Pt-complex (free of platinum black), heating to 70°C for 2 h (water-bath); standing overnight (room temp.), cooling in ice, collection (filtration), washing (water, EtOH, ether), drying (vac.); elem. anal.;

Reference yield: 52.0%

cis-dichloro-trans-ammonia(cyclohexylamine)platinum (159701-67-4,99038-38-7,174691-91-9) + dihydrogen peroxide (7722-84-1) → (OC-6-43)-amminedichloro(cyclohexanamine)dihydroxyplatinum(IV) (124721-03-5,1313200-52-0,146924-11-0)

Guidance literature:

In water; refluxing for 2 h; pptn. on cooling in ice, collection (filtration), washing (water, Me2CO), drying in air; elem. anal.;

DOI:10.1021/ic960983u

Reference yield: 45.83%

amminedichloro(cyclohexylamine)platinum(II) + dihydrogen peroxide (7722-84-1) → C6H18Cl2N2O2Pt (124721-03-5,1313200-52-0,146924-11-0)

Guidance literature:

at 50 ℃; for 4h;

upstream raw materials:

cis-dichloro-trans-ammonia(cyclohexylamine)platinum

dihydrogen peroxide

C₆H₂₀N₂O₂Pt⁽²⁺⁾

cyclohexylamine

Downstream raw materials:

(OC₆-6-22)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV)

(OC₆-6-12)-bis(acetato-O)amminedichloro(cyclohexylamine)platinum(IV)

L-cystine

trans-[Pt(OH)2(c-C₆H₁₁NH₂)(NH₃)]

Refernces

• 1、 -. "Preparation method and application of novel Pt(IV) complex with tumor targeting function". Paragraph 0074; 0075. . Retrieved 2019/10/01.
• 2、 -. "A compound with anticancer activity and its preparation method". Paragraph 0107; 0108. . Retrieved 2017/02/28.