quinolin-8-yl 4-chlorobenzoate

Base Information

• Chemical Name: quinolin-8-yl 4-chlorobenzoate
• CAS No.: 92866-20-1
• Molecular Formula: C₁₆H₁₀ClNO₂
• Molecular Weight: 283.714
• Mol file: 92866-20-1.mol

Synonyms:quinolin-8-yl 4-chlorobenzoate

Chemical Property of quinolin-8-yl 4-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of quinolin-8-yl 4-chlorobenzoate

There total 4 articles about quinolin-8-yl 4-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

bromochlorobenzene (106-39-8) + 8-acetyloxyquinoline (2598-29-0) → quinolin-8-yl 4-chlorobenzoate (92866-20-1)

Guidance literature:

With chloro[(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2’-amino-1,1’-biphenyl)]palladium(II); triethylamine; In toluene; at 120 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;

DOI:10.1055/s-0040-1707187

Reference yield: 83.0%

8-quinolinol (148-24-3,24804-14-6) + 4-chloro-benzoyl chloride (122-01-0) → quinolin-8-yl 4-chlorobenzoate (92866-20-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2018.09.037

Reference yield:

8-quinolinol (148-24-3,24804-14-6) → quinolin-8-yl 4-chlorobenzoate (92866-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1 h / 60 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C

2.1: triethylamine; chloro[(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2’-amino-1,1’-biphenyl)]palladium(II) / toluene / 0.33 h / 120 °C / Microwave irradiation; Inert atmosphere

With chloro[(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2’-amino-1,1’-biphenyl)]palladium(II); triethylamine; In toluene;

DOI:10.1055/s-0040-1707187

upstream raw materials:

8-quinolinol

4-chloro-benzoyl chloride

bromochlorobenzene

8-acetyloxyquinoline