2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Base Information

Chemical Name:2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid
CAS No.:1373544-94-5
Molecular Formula:C₂₂H₂₄ClN₃O₂
Molecular Weight:397.904
Hs Code.:

Synonyms:2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

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Chemical Property of 2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

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Technology Process of 2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

There total 3 articles about 2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1373546-39-4
2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

: 62-57-7
2-Aminoisobutyric acid

: 1373544-94-5
2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile; 2-Aminoisobutyric acid; With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; at 120 ℃; for 16h;

With ammonium chloride; In water; dimethyl sulfoxide; ethyl acetate; at 20 ℃;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373544-94-5
2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ytterbium(III) triflate / acetonitrile / 18 h / 85 °C / sealed tube

2.1: potassium carbonate / copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C

2.2: 20 °C

With potassium carbonate; copper(l) iodide; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 21803-75-8
4-amino-3-chlorobenzonitrile

: 1373544-94-5
2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: ytterbium(III) triflate / acetonitrile / 18 h / 85 °C / sealed tube

2.1: potassium carbonate / copper(l) iodide / dimethyl sulfoxide / 16 h / 120 °C

2.2: 20 °C

With potassium carbonate; copper(l) iodide; ytterbium(III) triflate; In dimethyl sulfoxide; acetonitrile;