2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

Base Information

Chemical Name:2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile
CAS No.:1373546-39-4
Molecular Formula:C₁₈H₁₆BrClN₂
Molecular Weight:375.695
Hs Code.:

Synonyms:2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

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Chemical Property of 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

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Technology Process of 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

There total 1 articles about 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 3132-99-8
m-bromobenzoic aldehyde

: 21803-75-8
4-amino-3-chlorobenzonitrile

: 115-11-7,15220-85-6
isobutene

: 1373546-39-4
2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

Guidance literature:: ytterbium(III) triflate; In acetonitrile; at 85 ℃; for 18h; sealed tube;

Reference yield: 30.1%

: 22059-21-8
aminocyclopropane-1-carboxylic acid

: 1373546-39-4
2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

: 1373544-72-9
1-[3-(8-chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-cyclopropanecarboxylic acid

Guidance literature:: aminocyclopropane-1-carboxylic acid; 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile; With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; at 120 ℃; for 16h;

With ammonium chloride; In water; dimethyl sulfoxide; ethyl acetate; at 20 ℃;

Reference yield: 30.0%

: 1373546-39-4
2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile

: 62-57-7
2-Aminoisobutyric acid

: 1373544-94-5
2-[3-(8-Chloro-6-cyano-4,4-dimethyl-1,2,3,4-tetrahydro-quinolin-2-yl)-phenylamino]-2-methyl-propionic acid

Guidance literature:: 2-(3-bromo-phenyl)-8-chloro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-carbonitrile; 2-Aminoisobutyric acid; With potassium carbonate; copper(l) iodide; In dimethyl sulfoxide; at 120 ℃; for 16h;

With ammonium chloride; In water; dimethyl sulfoxide; ethyl acetate; at 20 ℃;