N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

Base Information

Chemical Name:N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide
CAS No.:1314042-56-2
Molecular Formula:C₂₀H₂₇FN₄O₃S
Molecular Weight:422.524
Hs Code.:

Synonyms:N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

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Chemical Property of N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

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Technology Process of N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

There total 5 articles about N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1184-85-6
N-methylmethane sulphonamide

: 1314042-55-1
5-(diethylcarbamoyl)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-2-yl-4-methylbenzenesulfonate

: 1314042-56-2
N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

Guidance literature:: With potassium carbonate; In toluene; Reflux;

Reference yield:

: 1314042-53-9
N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide

: 1314042-56-2
N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid; sodium nitrite / 5 - 35 °C

1.3: 3 h

2.1: potassium carbonate / ethyl acetate / 25 - 35 °C / Reflux

3.1: potassium carbonate / toluene / Reflux

With nitric acid; potassium carbonate; sodium nitrite; In ethyl acetate; toluene;

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 1314042-56-2
N,N-diethyl-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethane sulfonamido)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / Reflux

2.1: copper(l) chloride; sulfuric acid / methanol / Reflux

3.1: nitric acid; sodium nitrite / 5 - 35 °C

3.3: 3 h

4.1: potassium carbonate / ethyl acetate / 25 - 35 °C / Reflux

5.1: potassium carbonate / toluene / Reflux

With sulfuric acid; nitric acid; potassium carbonate; copper(l) chloride; sodium nitrite; In methanol; dimethyl sulfoxide; ethyl acetate; toluene;