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Bisoprolol fumarate

Base Information Edit
  • Chemical Name:Bisoprolol fumarate
  • CAS No.:104344-23-2
  • Molecular Formula:C4H4O4*2C18H31NO4
  • Molecular Weight:766.97
  • Hs Code.:2922190900
  • NSC Number:759181
  • UNII:U057CX04H0
  • Wikidata:Q27290514
  • NCI Thesaurus Code:C28871
  • RXCUI:142146
  • ChEMBL ID:CHEMBL1200708
  • Mol file:104344-23-2.mol
Bisoprolol fumarate

Synonyms:Bisoprolol;Bisoprolol Fumarate;Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer;Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer;Bisoprolol Hydrochloride;Bisoprolol Methanesulfonate Salt;Bisoprolol, (+-)-Isomer;Bisoprolol, (-)-Isomer;Bisoprolol, Fumarate (1:1) Salt;Bisoprolol, Fumarate (2:1) Salt;CL 297939;CL-297939;CL297939;Concor;EMD 33512;EMD-33512;EMD33512;Fumarate, Bisoprolol;Hydrochloride, Bisoprolol

Suppliers and Price of Bisoprolol fumarate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • BisoprololHemifumarate
  • 50mg
  • $ 195.00
  • Sigma-Aldrich
  • Bisoprolol fumarate European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Bisoprolol for peak identification European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Bisoprolol for system suitability European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Bisoprolol for system suitability European Pharmacopoeia (EP) Reference Standard
  • y0000813
  • $ 190.00
  • Sigma-Aldrich
  • Bisoprolol fumarate European Pharmacopoeia (EP) Reference Standard
  • y0000812
  • $ 190.00
  • Sigma-Aldrich
  • Bisoprolol for peak identification European Pharmacopoeia (EP) Reference Standard
  • y0000877
  • $ 190.00
  • Sigma-Aldrich
  • Bisoprolol hemifumarate salt ≥98% (HPLC), solid
  • 10mg
  • $ 134.00
  • Sigma-Aldrich
  • Bisoprolol fumarate United States Pharmacopeia (USP) Reference Standard
  • 200mg
  • $ 366.00
  • Sigma-Aldrich
  • Bisoprolol hemifumarate salt ≥98% (HPLC), solid
  • 50mg
  • $ 537.00
Total 205 raw suppliers
Chemical Property of Bisoprolol fumarate Edit
Chemical Property:
  • Appearance/Colour:white to offf-white powder 
  • Vapor Pressure:1.06E-08mmHg at 25°C 
  • Melting Point:100 °C 
  • Boiling Point:445 °C at 760 mmHg 
  • Flash Point:222.9 °C 
  • PSA:134.55000 
  • Density:1.033 g/cm3 
  • LogP:2.46860 
  • Storage Temp.:Store at RT 
  • Solubility.:DMSO: >20 mg/mL 
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:9
  • Rotatable Bond Count:14
  • Exact Mass:441.23626707
  • Heavy Atom Count:31
  • Complexity:397
Purity/Quality:

99% *data from raw suppliers

BisoprololHemifumarate *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn,IrritantXi 
  • Hazard Codes:Xn,Xi 
  • Statements: 22 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
  • Isomeric SMILES:CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=C/C(=O)O)\C(=O)O
  • Recent ClinicalTrials:Pharmacogenetic Study of Bisoprolol in Egyptian Patients With Acute Coronary Syndrome
  • Recent EU Clinical Trials:A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of chronic obstructive pulmonary disease.
  • Recent NIPH Clinical Trials:Phase III clinical study of TY-0201 in patients with chronic atrial fibrillation -Confirmatory Study-
  • Indications Treatment of essential hypertension. As first-line antihypertensive agents, it can be used alone or combined with diuretics and vasodilator drugs. Angina and myocardial infarction. Arrhythmias, such as the rapid ventricular arrhythmia, ventricular contraction. In recent years, bisoprolol fumarate is also tempted used for the treatment of heart failure. It is effective for moderate to severe chronic stable heart failure which previously receiving ACE inhibitors, diuretics and cardiac glycosides medications associated with ventricular systolic dysfunction (ejection fraction ≤35%) . The above information is edited by the lookchem of Tian Ye.
  • Drug interactions 1.when bisoprolol fumarate is used in combination with other anti-hypertensive drugs, the antihypertensive effect is enhanced . 2. when bisoprolol fumarate is used in combination with reserpine, methyldopa, clonidine or guanfacine, the heart rate can be slowed down. 3. when bisoprolol fumarate is used in combination with reserpine, reserpine needs to be stopped a few days after stop of this product . 4. when bisoprolol fumarate is used in combination with nifedipine, the antihypertensive effect of this product can be enhanced . 5. when bisoprolol fumarate is used in combination with verapamil or diltiazem ketones calcium icon antagonists or other antiarrhythmic drugs , there is the need for patient care, because they can cause hypotension, bradycardia and others. Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: NSAIDs antagonise hypotensive effect. Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; increased risk of myocardial depression and bradycardia with flecainide. Antibacterials: concentration reduced by rifampicin. Antidepressants: enhanced hypotensive effect with MAOIs. Antihypertensives; enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin. Antimalarials: increased risk of bradycardia with mefloquine. Antipsychotics enhanced hypotensive effect with phenothiazines. Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil. Cytotoxics: possible increased risk of bradycardia with crizotinib. Diuretics: enhanced hypotensive effect. Fingolimod: possibly increased risk of bradycardia. Moxisylyte: possible severe postural hypotension. Sympathomimetics: severe hypertension with adrenaline and noradrenaline, and possibly with dobutamine.
  • Description Bisoprolol fumarate is a β1-selective adrenergic blocker useful in the treatment of essential hypertension.
  • Uses antiinflammatory A selective β-adrenergic blocker. Used as an antihypertensive. semi-synthetic kanamycin-derived aminoglycoside antibiotic Labeled Bisoprolol, intended for use as an internal standard for the quantification of Bisoprolol by GC- or LC-mass spectrometry. A selective a-adrenergic blocker. Used as an antihypertensive A selective α-adrenergic blocker. Used as an antihypertensive.
  • Therapeutic Function Beta-adrenergic blocker
  • Clinical Use Beta-1 adrenoceptor blocker: Hypertension Angina Adjunctive treatment for heart failure
Technology Process of Bisoprolol fumarate

There total 2 articles about Bisoprolol fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
In chloroform; at 20 ℃; for 15h; Concentration; Temperature; Time;
upstream raw materials:

bisoprolol

(2E)-but-2-enedioic acid

Downstream raw materials:

2-(1-methylethoxy)-ethanol

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