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| CAS No.: | 104344-23-2 |
|---|---|
| Name: | Bisoprolol fumarate |
| Molecular Structure: | |
|
|
|
| Formula: | C18H31NO4.C4H4O4 |
| Molecular Weight: | 766.97 |
| Synonyms: | (+-)-1-(p-((2-Isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanol hemifumarate;Bisoprolol hemifumarate;2-Propanol,1-[4-[[2-(1-methylethoxy)ethoxy]- methyl]phenoxy]-3-[(1-methylethyl)amino]-,(2E)-2-butenedioate (2:1) (salt);but-2-enedioic acid; 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol;Monocor;Soprol;2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt);Concor;Zebeta;Godal;(+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt);Emcor;Maintate;Bisomerck;Bisobloc;Biso-Puren;Fondril; |
| EINECS: | 600-557-5 |
| Density: | 1.033 g/cm3 |
| Melting Point: | 100 °C |
| Boiling Point: | 445 °C at 760 mmHg |
| Flash Point: | 222.9 °C |
| Solubility: | >20 mg/mL in DMSO |
| Appearance: | white to offf-white powder |
| Hazard Symbols: |
 Xn, Xi
|
| Risk Codes: | 22 |
| PSA: | 134.55000 |
| LogP: | 2.46860 |
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Chemistry
Molecule structure of Bisoprolol fumarate (CAS NO.104344-23-2):
Molecular Formula: C18H31NO4.C4H4O4
Molecular Weight: 441.52 g/mol
Melting Point: 100 °C
Flash Point: 222.9 °C
Enthalpy of Vaporization: 74.08 kJ/mol
Boiling Point: 445 °C at 760 mmHg
Vapour Pressure: 1.06E-08 mmHg at 25 °C
Solubility DMSO: >20 mg/mL
InChI: InChI=1/C18H31NO4.C4H4O4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4;5-3(6)1-2-4(7)8/h5-8,14-15,17,19-20H,9-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChIKey: RZPZLFIUFMNCLY-WLHGVMLRBA
Product Categories: Pharmaceutical material and intermeidates; APIs;Intermediates & Fine Chemicals; Pharmaceuticals; Adrenoceptor
Uses
Bisoprolol fumarate (CAS NO.104344-23-2) is a selective a-adrenergic blocker. It is used as an antihypertensive.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LDLo | oral | 40mg/kg (40mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2321, 1989. |
| mouse | LD50 | intravenous | 111mg/kg (111mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
| mouse | LD50 | oral | 678mg/kg (678mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
| rat | LD50 | intravenous | 39mg/kg (39mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
| rat | LD50 | oral | 940mg/kg (940mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 2313, 1989. |
Safety Profile
Hazard Codes: 
Xn, 
Xi
Risk Statements: 22
R22:Harmful if swallowed.
WGK Germany: 3
RTECS: UB8390000
Beta-blockers can precipitate asthma and this effect can be dangerous. Beta-blockers should be avoided in patients with a history of asthma or bronchospasm; if there is no alternative, a cardioselective beta-blocker can be used with extreme caution under specialist supervision. atenolol, bisoprolol, METOPROLOL, nebivolol, and (to a lesser extent) ACEBUTOLOL, have less effect on the beta2 (bronchial) receptors and are, therefore, relatively cardioselective, but they are not cardiospecific. They have a lesser effect on airways resistance but are not free of this side-effect.
Specification
Bisoprolol fumarate (CAS NO.104344-23-2) is also named as (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol fumarate (2:1) (salt) ; (+-)-1-(p-((2-Isopropoxyethoxy)methyl)phenoxy)-3-isopropylamino-2-propanol hemifumarate ; 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, (+-)-, (E)-2-butenedioate (2:1) (salt) ; Biso-Puren ; Bisobloc ; Bisomerck ; Bisoprolol hemifumarate ; CL 297,939 ; Concor ; Concor Plus Forte ; Detensiel ; EMD 33512 ; Emcor ; Emvoncor ; Eurtadal ; Fondril ; Godal ; Isoten ; Maintate ; Monocor ; Soprol ; TA-4708 ; UNII-UR59KN573L ; Zabesta ; Zebeta . Bisoprolol fumarate (CAS NO.104344-23-2) is toxic. It is flammable. It will produce toxic nitrogen oxide fumes in fire. So the storage environment should be ventilate, low-temperature and dry.