(S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Name:(S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1187029-57-7
Molecular Formula:C₂₉H₄₀N₄O₅
Molecular Weight:524.66
Hs Code.:

Synonyms:(S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of (S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of (S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

There total 7 articles about (S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-43-4
2-methylpropyl(methyl)amine

: 1187028-52-9
3-formyl-4-methylbenzoic acid

: 1187029-57-7
(S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.ejmech.2016.03.048

Reference yield:

: 69526-89-2
3-formyl-4-methylbenzoic acid

: 1187029-57-7
(S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 18 h / 20 °C

2.1: 1,4-dioxane / 2 h / 100 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; 1-methyl-pyrrolidin-2-one / 18 h / 0 - 20 °C

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.03.048

Reference yield:

: 24589-99-9
methyl 3-formyl-4-hydroxybenzoate

: 1187029-57-7
(S)-N-(3-(2-ethyl-4-(5-(3-((isobutyl(methyl)amino)methyl)-4-methylphenyl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 1 h / 0 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; toluene / 1 h / 75 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: 1,4-dioxane / 2 h / 100 °C

5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane; 1-methyl-pyrrolidin-2-one / 18 h / 0 - 20 °C

With pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2016.03.048