Technology Process of 2-(3-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide
There total 11 articles about 2-(3-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl 4-(4-((4-(2-(3-(2-amino-2-oxoethyl)pyrazin-2-yl)ethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 17h;
With
sodium hydroxide;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere; sealed tube
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.03 h / 0 °C
3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Inert atmosphere; microwave irradiation
4.1: triethylamine; hydrogen / N,N-dimethyl-formamide / 17 h
5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C
5.2: 2 h
6.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C
With
lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.03 h / 0 °C
2.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Inert atmosphere; microwave irradiation
3.1: triethylamine; hydrogen / N,N-dimethyl-formamide / 17 h
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C
4.2: 2 h
5.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C
With
lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
