2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

Base Information

Chemical Name:2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide
CAS No.:1393900-65-6
Molecular Formula:C₂₅H₂₈F₃N₇O
Molecular Weight:499.539
Hs Code.:

Synonyms:2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

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Chemical Property of 2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

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Technology Process of 2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

There total 12 articles about 2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1393900-64-5
2-(3-(2-(2-((4-(piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

: 1393900-65-6
2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

Guidance literature:: With methanol; sodium tris(acetoxy)borohydride; In water; at 20 ℃; for 3h;

Reference yield:

: 914360-82-0
ethyl 2-(3-chloropyrazin-2-yl)acetate

: 1393900-65-6
2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere; sealed tube

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.03 h / 0 °C

3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Inert atmosphere; microwave irradiation

4.1: triethylamine; hydrogen / N,N-dimethyl-formamide / 17 h

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C

5.2: 2 h

6.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

7.1: sodium tris(acetoxy)borohydride; methanol / water / 3 h / 20 °C

With methanol; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1393901-51-3
ethyl 2-(3-((trimethylsilyl)ethynyl)pyrazin-2-yl)acetate

: 1393900-65-6
2-(3-(2-(2-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)pyrazin-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.03 h / 0 °C

2.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 0.25 h / 120 °C / Inert atmosphere; microwave irradiation

3.1: triethylamine; hydrogen / N,N-dimethyl-formamide / 17 h

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 17 h / 20 °C

4.2: 2 h

5.1: trifluoroacetic acid / dichloromethane / 17 h / 20 °C

6.1: sodium tris(acetoxy)borohydride; methanol / water / 3 h / 20 °C

With methanol; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; hydrogen; sodium tris(acetoxy)borohydride; triethylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;