N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

Base Information

Chemical Name:N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide
CAS No.:1360430-67-6
Molecular Formula:C₂₇H₂₂ClN₅O₃
Molecular Weight:499.956
Hs Code.:

Synonyms:N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

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Chemical Property of N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

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Technology Process of N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

There total 17 articles about N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 848139-78-6
6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile

: 814-68-6,25189-84-8
acryloyl chloride

: 1360430-67-6
N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

Guidance literature:: With trimethylamine; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃;
DOI:10.1007/s11696-019-00686-0

Reference yield: 35.0%

: 848139-78-6
6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile

: 79-10-7
acrylic acid

: 1360430-67-6
N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1021/jm201507x

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1360430-67-6
N-(4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine hydrochloride / isopropyl alcohol / Reflux

2: hydrogenchloride / water / 5 h / Reflux

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C

With hydrogenchloride; pyridine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm201507x