3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate

Base Information

Chemical Name:3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate
CAS No.:1444821-15-1
Molecular Formula:C₁₈H₂₁N₃O₆S
Molecular Weight:407.447
Hs Code.:

Synonyms:3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate

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Chemical Property of 3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate

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Technology Process of 3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate

There total 2 articles about 3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160517-36-2
5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate

: 108-23-6
isopropyl chloroformate

: 1444821-15-1
3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.04.054

Reference yield:

: 39562-17-9
methyl 2-(3-nitrophenylmethylene)acetoacetate

: 1444821-15-1
3-isopropyl 5-methyl 4-(3-nitrophenyl)-1,4-dihydro-6-methyl-2-(methylthio)-5-pyrimidinedicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate / N,N-dimethyl-formamide / 80 °C

2: sodium hydride / mineral oil; tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

With sodium acetate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 1: |Michael Addition;
DOI:10.1016/j.bmc.2013.04.054