1-piperidine-3,4,5-trimethoxybenzene

Base Information

• Chemical Name: 1-piperidine-3,4,5-trimethoxybenzene
• CAS No.: 108103-61-3
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.326
• Mol file: 108103-61-3.mol

Synonyms:1-piperidine-3,4,5-trimethoxybenzene

Chemical Property of 1-piperidine-3,4,5-trimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-piperidine-3,4,5-trimethoxybenzene

There total 3 articles about 1-piperidine-3,4,5-trimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

piperidine (110-89-4) + 1-bromo-3,4,5-trimethoxybenzene (2675-79-8) → 1-piperidine-3,4,5-trimethoxybenzene (108103-61-3)

Guidance literature:

With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate; In N,N-dimethyl-formamide; at 95 ℃; for 20h; Inert atmosphere;

DOI:10.1039/b821212k

Reference yield:

1,5-dibromo-pentane (111-24-0) + 3,4,5-Trimethoxyaniline (24313-88-0) → 1-piperidine-3,4,5-trimethoxybenzene (108103-61-3)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03004

Reference yield:

piperidine (110-89-4) + 2,3,4-trimethoxybromobenzene (10385-36-1) → 1-piperidine-3,4,5-trimethoxybenzene (108103-61-3)

Guidance literature:

With sodamine; Yield given. Multistep reaction; 1.) 15 min, 2.) RT;

DOI:10.1021/jo00388a058

upstream raw materials:

piperidine

2,3,4-trimethoxybromobenzene

1-bromo-3,4,5-trimethoxybenzene

1,5-dibromo-pentane