1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester
• CAS No.: 1401863-99-7
• Molecular Formula: C₂₁H₁₈N₂O₃
• Molecular Weight: 346.386
• Mol file: 1401863-99-7.mol

Synonyms:1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester

Chemical Property of 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester

There total 8 articles about 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(4-methoxyphenyl)-β-carboline-3-carboxylic acid methyl ester (113247-18-0) + methyl iodide (74-88-4) → 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester (1401863-99-7)

Guidance literature:

1-(4-methoxyphenyl)-β-carboline-3-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield: 77.8%

→ 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester (1401863-99-7)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 1h; Cooling with ice;

In N,N-dimethyl-formamide; for 3h;

Reference yield:

L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → 1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carboxylic acid methyl ester (1401863-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Acidic conditions

2: sulfuric acid

3: sodium hydroxide / N,N-dimethyl-formamide / 48 h / 20 °C

With sulfuric acid; sodium hydroxide; In N,N-dimethyl-formamide; 1: Pictet-Spengler cyclisation;

DOI:10.1016/j.bmc.2011.08.059

upstream raw materials:

1-(4-methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid

1-(4-methoxyphenyl)-β-carboline-3-carboxylic acid methyl ester

methyl iodide

4-methoxy-benzaldehyde

Downstream raw materials:

N'-benzylidene-1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carbohydrazide

N'-(2-chlorobenzylidene)-1-(4-methoxyphenyl)-9-methyl-β-carboline-3-carbohydrazide

C₂₂H₂₂N₄O₂*ClH