2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

Base Information

Chemical Name:2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile
CAS No.:1371608-44-4
Molecular Formula:C₁₃H₁₀ClF₃N₂O₃
Molecular Weight:334.682
Hs Code.:

Synonyms:2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

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Chemical Property of 2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

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Technology Process of 2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

There total 7 articles about 2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₁₈ClF₃N₂O₃Si

: 1371608-43-3
2-chloro-3-methyl-4-((R)-2-oxo-4-((S)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

: 1371608-44-4
2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

Guidance literature:: With water; potassium hydroxide; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 1182367-37-8
(R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid

: 1371608-43-3
2-chloro-3-methyl-4-((R)-2-oxo-4-((S)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

: 1371608-44-4
2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / diethyl ether

1.2: 3 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere

3.1: ethanol; sodium tetrahydroborate / 4 h / 0 - 20 °C

4.1: Dess-Martin periodane / acetonitrile / 2 h / 0 - 20 °C

5.1: cesium fluoride / tetrahydrofuran / 2 h / 0 °C

6.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 0 °C

With sodium tetrahydroborate; ethanol; water; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; cesium fluoride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 796600-15-2
2-chloro-4-fluoro-3-methylbenzonitrile

: 1371608-43-3
2-chloro-3-methyl-4-((R)-2-oxo-4-((S)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

: 1371608-44-4
2-chloro-3-methyl-4-((R)-2-oxo-4-((R)-2,2,2-trifluoro-1-hydroxyethyl)oxazolidin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / dimethyl sulfoxide / 12 h / 90 °C

1.2: pH ~ 3

2.1: potassium hydroxide / diethyl ether

2.2: 3 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / -78 - 20 °C / Inert atmosphere

4.1: ethanol; sodium tetrahydroborate / 4 h / 0 - 20 °C

5.1: Dess-Martin periodane / acetonitrile / 2 h / 0 - 20 °C

6.1: cesium fluoride / tetrahydrofuran / 2 h / 0 °C

7.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 0 °C

With sodium tetrahydroborate; ethanol; water; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; cesium fluoride; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile;