Technology Process of 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-(methyloxy)phenyl]butanoic acid
There total 14 articles about 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-(methyloxy)phenyl]butanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: caesium carbonate; tri-tert-butyl phosphine / tris-(dibenzylideneacetone)dipalladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: ammonium chloride; iron / 90 °C
3.1: sodium nitrite; hydrogen bromide / acetonitrile; water / 0.17 h / 0 °C
3.2: 1 h / 50 °C
4.1: tricyclohexylphosphine; potassium acetate / tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 0.75 h / 150 °C / Inert atmosphere; Sealed; Microwave irradiation
5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation
6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 0.25 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation
7.1: water; lithium hydroxide / isopropyl alcohol / 2 h / 79 °C
With
potassium phosphate; tri-tert-butyl phosphine; water; hydrogen bromide; potassium acetate; iron; ammonium chloride; caesium carbonate; lithium hydroxide; sodium nitrite; tricyclohexylphosphine;
tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
ethyl 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-5-fluoro-2-(methyloxy)phenyl]butanoate;
With
water; lithium hydroxide;
In
isopropyl alcohol;
at 79 ℃;
for 2h;
With
acetic acid;
In
water; isopropyl alcohol;
- Guidance literature:
-
ethyl 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-(methyloxy)phenyl]butanoate;
With
lithium hydroxide;
In
water; isopropyl alcohol;
at 79 ℃;
for 2h;
With
acetic acid;
In
water; isopropyl alcohol;
