6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

Base Information

Chemical Name:6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide
CAS No.:1374213-83-8
Molecular Formula:C₂₇H₃₀N₆O₂
Molecular Weight:470.574
Hs Code.:

Synonyms:6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

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Chemical Property of 6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

Chemical Property:

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Technology Process of 6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

There total 11 articles about 6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374213-82-7
4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

: 108-24-7
acetic anhydride

: 1374213-83-8
6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 100-47-0
benzonitrile

: 1374213-83-8
6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) isopropylate / dichloromethane; diethyl ether / 1 h / -60 - 20 °C

1.2: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 60 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 15 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With titanium(IV) isopropylate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; In 1,4-dioxane; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 73027-79-9
4,6-dichloro-nicotinic acid

: 1374213-83-8
6-(3-(4-acetylpiperazin-1-yl)phenylamino)-4-(1-phenylcyclopropylamino)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 60 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 15 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;