4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

Base Information

Chemical Name:4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide
CAS No.:1374213-82-7
Molecular Formula:C₂₅H₂₈N₆O
Molecular Weight:428.537
Hs Code.:

Synonyms:4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

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Chemical Property of 4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

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Technology Process of 4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

There total 11 articles about 4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374215-26-5
C₃₀H₃₆N₆O₃

: 1374213-82-7
4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;

Reference yield:

: 73027-79-9
4,6-dichloro-nicotinic acid

: 1374213-82-7
4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 48 h / 60 °C

3.1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 15 h / 80 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 206879-94-9
4-(3-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1374213-82-7
4-(1-phenylcyclopropylamino)-6-(3-(piperazin-1-yl)phenylamino)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / ethanol; tetrahydrofuran / 16 h / 760.05 Torr

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / palladium diacetate / 1,4-dioxane / 15 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h

With hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; palladium on activated charcoal; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;