4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

Base Information

Chemical Name:4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide
CAS No.:1352836-98-6
Molecular Formula:C₂₃H₂₄N₄O₃
Molecular Weight:404.469
Hs Code.:

Synonyms:4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

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Chemical Property of 4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

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Technology Process of 4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

There total 11 articles about 4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1352836-94-2
benzyl 3-(1-carbamoyl-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate

: 1352836-98-6
4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; for 1.5h;

Reference yield:

: 2380-86-1
6-hydroxy-1H-indole

: 1352836-98-6
4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 75 °C

2.1: 12 h / 140 °C

3.1: zinc; ammonium acetate / tetrahydrofuran; methanol / 5 h / Inert atmosphere

4.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

4.3: 3 h / 120 °C

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2.5 h / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1.5 h

With 4-methyl-morpholine; hydrogenchloride; ammonium acetate; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352836-98-6
4-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-3-methyl-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 95 °C

4.1: 12 h / 140 °C

5.1: zinc; ammonium acetate / tetrahydrofuran; methanol / 5 h / Inert atmosphere

6.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

6.3: 3 h / 120 °C

7.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 2.5 h / Inert atmosphere

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 1.5 h

With 4-methyl-morpholine; hydrogenchloride; ammonium acetate; hydrogen; diisobutylaluminium hydride; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;