(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

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Chemical Name:(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride
CAS No.:1429746-52-0
Molecular Formula:C₂₆H₂₃FN₆O₃*ClH
Molecular Weight:522.966
Hs Code.:

Synonyms:(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

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Chemical Property of (2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

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Technology Process of (2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

There total 2 articles about (2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1429747-55-6
5-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-N-(pyridin-4-yl)pyrimidin-4-amine

: 1429746-52-0
(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

Guidance literature:: With hydrogenchloride; In acetonitrile; at 20 ℃; for 18h;

Reference yield:

: 1429745-91-4
2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol

: 1429746-52-0
(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 42 h / 50 - 90 °C

2: hydrogenchloride / acetonitrile / 18 h / 20 °C

With hydrogenchloride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;