2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol

Base Information

• Chemical Name: 2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol
• CAS No.: 1429745-91-4
• Molecular Formula: C₂₃H₁₇FN₆O
• Molecular Weight: 412.426

Synonyms:2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol

Chemical Property of 2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol

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Technology Process of 2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol

There total 1 articles about 2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol (1429745-91-4)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 190 ℃; for 1h; Inert atmosphere;

Reference yield: 44.0%

2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol (1429745-91-4) + (R)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl bromide (14437-87-7) → 5-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-N-(pyridin-4-yl)pyrimidin-4-amine (1429747-55-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 - 90 ℃; for 42h;

Reference yield: 19.8%

1-bromo-2,3-propanediol (4704-77-2) + 2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol (1429745-91-4) → {2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-8-(pyridin-4-yl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-7-yl}methanol (1429746-70-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

Downstream raw materials:

(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol

{2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-8-(pyridin-4-yl)-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-7-yl}methanol

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