(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

Base Information

Chemical Name:(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol
CAS No.:1429746-38-2
Molecular Formula:C₂₆H₂₃FN₆O₃
Molecular Weight:486.505
Hs Code.:

Synonyms:(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

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Chemical Property of (2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

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Technology Process of (2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

There total 3 articles about (2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1429746-52-0
(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)-pyrimidin-5-yl}oxy)propane-1,2-diol hydrochloride

: 1429746-38-2
(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

Guidance literature:: With sodium hydroxide; In water; at 20 ℃; for 3h;

Reference yield:

: 1429745-91-4
2-{1-(2-fluorobenzyl)-1H-indazol-3-yl}-4-[(pyridin-4-yl)amino]pyrimidin-5-ol

: 1429746-38-2
(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 42 h / 50 - 90 °C

2: hydrogenchloride / acetonitrile / 18 h / 20 °C

3: sodium hydroxide / water / 3 h / 20 °C

With hydrogenchloride; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1429747-55-6
5-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}-2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-N-(pyridin-4-yl)pyrimidin-4-amine

: 1429746-38-2
(2R)-3-({2-[1-(2-fluorobenzyl)-1H-indazol-3-yl]-4-(pyridin-4-ylamino)pyrimidin-5-yl}oxy)propane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / acetonitrile / 18 h / 20 °C

2: sodium hydroxide / water / 3 h / 20 °C

With hydrogenchloride; sodium hydroxide; In water; acetonitrile;