4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate

Base Information

• Chemical Name: 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate
• CAS No.: 1402231-69-9
• Molecular Formula: C₁₈H₂₅NO₈
• Molecular Weight: 383.398
• Mol file: 1402231-69-9.mol

Synonyms:4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate

Chemical Property of 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate

There total 4 articles about 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester (176375-42-1) → 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate (1402231-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol; tetrahydrofuran / 3 h / 0 °C

2: pyridine hydrochloride / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; pyridine hydrochloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/anie.201202684

Reference yield:

4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester (176375-41-0) → 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate (1402231-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid / 3 h / -2 °C

2: sodium tetrahydroborate / ethanol; tetrahydrofuran / 3 h / 0 °C

3: pyridine hydrochloride / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; nitric acid; pyridine hydrochloride; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1002/anie.201202684

Reference yield:

vanillin (121-33-5,8014-42-4) → 4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoate (1402231-69-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: nitric acid / 3 h / -2 °C

3: sodium tetrahydroborate / ethanol; tetrahydrofuran / 3 h / 0 °C

4: pyridine hydrochloride / dichloromethane / 2 h / 20 °C

With sodium tetrahydroborate; nitric acid; pyridine hydrochloride; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201202684

upstream raw materials:

4-(4-formyl-2-methoxyphenoxy)butanoic acid methyl ester

vanillin

Methyl 4-bromobutyrate

4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoic acid methyl ester

Downstream raw materials:

4-(2-methoxy-5-nitro-4-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)phenoxy)butanoic acid