2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester

Base Information

• Chemical Name: 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester
• CAS No.: 372523-13-2
• Molecular Formula: C₂₂H₁₇Cl₂NO₄S
• Molecular Weight: 462.353
• Mol file: 372523-13-2.mol

Synonyms:2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester

Chemical Property of 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester

There total 2 articles about 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

4-(2-hydroxyethyl)benzonitrile (69395-13-7) + 2,3-dichlorobenzenesulfonic acid 3-hydroxy-5-methylphenyl ester (189341-21-7) → 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester (372523-13-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/jm010833f

Reference yield:

dichlorobenzenesulfonyl chloride (82417-45-6) → 2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester (372523-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 20 percent / aq. NaHCO₃ / diethyl ether / 48 h / 20 °C

2: 42 percent / DEAD; PPh₃ / tetrahydrofuran / 16 h / 20 °C

With sodium hydrogencarbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; 2: Mitsunobu reaction;

DOI:10.1021/jm010833f

Reference yield: 50.0%

2,3-dichlorobenzenesulfonic acid 3-[2-(4-cyanophenyl)ethoxy]-5-methylphenyl ester (372523-13-2) → 2,3-dichloro-benzenesulfonic acid 3-[2-(4-aminomethyl-phenyl)-ethoxy]-5-methyl-phenyl ester

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; for 3.5h; Heating;

DOI:10.1021/jm010833f

upstream raw materials:

4-(2-hydroxyethyl)benzonitrile

2,3-dichlorobenzenesulfonic acid 3-hydroxy-5-methylphenyl ester

dichlorobenzenesulfonyl chloride

Refernces