methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

Base Information

Chemical Name:methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate
CAS No.:1307853-69-5
Molecular Formula:C₃₅H₃₄N₆O₇
Molecular Weight:650.691
Hs Code.:

Synonyms:methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

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Chemical Property of methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

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Technology Process of methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

There total 10 articles about methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.1%

: 1307853-40-2
5-[4'-(bromomethyl)biphenyl-2-yl]-1-(p-methoxybenzyl)-1H-tetrazole

: 57113-90-3
methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate

: 1307853-69-5
methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

Guidance literature:: With potassium carbonate; In acetonitrile; for 6h; Reflux; Inert atmosphere;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1307853-69-5
methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

With tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; acetonitrile;

Reference yield:

: 18039-42-4,3999-10-8
5-Phenyl-1H-tetrazole

: 1307853-69-5
methyl 2-(N-tert-butoxycarbonyl-N-{(2'-[1-(p-methoxybenzyl)-1H-tetrazol-5-yl]biphenyl-4-yl)methyl}amino)-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate; tetrabutylammomium bromide / chloroform; water / 2 h / 55 °C / Cooling with ice

1.2: 1 h

2.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 2 h / 140 °C / Inert atmosphere

3.1: sodium methylate / methanol / 1.5 h / 20 °C

4.1: phosphorus tribromide / tetrahydrofuran / 5.5 h / 0 - 20 °C

5.1: potassium carbonate / acetonitrile / 6 h / Reflux; Inert atmosphere

With tetrabutylammomium bromide; sodium methylate; phosphorus tribromide; sodium carbonate; potassium carbonate; triphenylphosphine; dichloro(1,5-cyclooctadiene)ruthenium(II) polymer; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; chloroform; water; acetonitrile;