N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

Base Information

Chemical Name:N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate
CAS No.:1361332-94-6
Molecular Formula:C₄H₄O₄*C₂₂H₃₈N₄O₅S
Molecular Weight:586.707
Hs Code.:

Synonyms:N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

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Chemical Property of N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

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Technology Process of N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

There total 3 articles about N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 3644-18-6
N-(2-(dimethylamino)ethyl)piperazine

: 766558-33-2
[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 1361332-94-6
N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

Guidance literature:: N-(2-(dimethylamino)ethyl)piperazine; [2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

(2E)-but-2-enedioic acid;
DOI:10.1021/jm2016057

Reference yield:

: 766558-32-1
[2-[[(4-methoxy-2,6-dimethylphenyl)sulfonyl]methylamino]ethoxy]acetic acid 1,1-dimethylethyl ester

: 1361332-94-6
N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

2: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm2016057

Reference yield:

: 55661-08-0
4-methoxy-2,6-dimethylbenzenesulfonyl chloride

: 1361332-94-6
N-[2-[2-[4-[2-(dimethylamino)ethyl]-1-piperazinyl]-2-oxoethoxy]ethyl]-4-methoxy-N,2,6-trimethylbenzenesulfonamide fumarate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 15 h / 20 °C

2: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 0.5 h / 10 - 20 °C

3: water; lithium hydroxide / tetrahydrofuran / 15 h / 20 °C

4: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; tetrabutyl-ammonium chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2016057