ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Base Information

Chemical Name:ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate
CAS No.:90246-98-3
Molecular Formula:C₁₈H₁₃ClFNO₄
Molecular Weight:361.757
Hs Code.:

Synonyms:ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Suppliers and Price of ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

There total 10 articles about ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 90246-98-3
ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: 79 percent / TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

2: 74 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

3: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

4: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

5: LiCl, Me₂SO, H₂O / 2 h / Heating

6: H₂SO₄ / Ambient temperature

7: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

8: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

9: 58 percent / 1 h / 90 °C

10: NaH / dimethylformamide / 4 h / Ambient temperature

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; boron tribromide; titanium tetrachloride; sodium hydride; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00374a014

Reference yield:

: 72482-14-5
3-chloro-2,4-dimethoxybenzaldehyde

: 90246-98-3
ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: 74 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

2: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

3: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

4: LiCl, Me₂SO, H₂O / 2 h / Heating

5: H₂SO₄ / Ambient temperature

6: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

7: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

8: 58 percent / 1 h / 90 °C

9: NaH / dimethylformamide / 4 h / Ambient temperature

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; boron tribromide; sodium hydride; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00374a014

Reference yield:

: 72482-15-6
3-chloro-2-hydroxy-4-methoxybenzaldehyde

: 90246-98-3
ethyl 8-chloro-5,6-dihydro-3-(o-fluorophenyl)furo[3,2-f]-1,2-benzisoxazole-6-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

2: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

3: LiCl, Me₂SO, H₂O / 2 h / Heating

4: H₂SO₄ / Ambient temperature

5: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

6: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

7: 58 percent / 1 h / 90 °C

8: NaH / dimethylformamide / 4 h / Ambient temperature

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; sodium hydride; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00374a014