ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

Base Information

Chemical Name:ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime
CAS No.:90246-99-4
Molecular Formula:C₂₀H₁₇ClFNO₆
Molecular Weight:421.809
Hs Code.:

Synonyms:ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

Suppliers and Price of ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

There total 9 articles about ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 108-24-7
acetic anhydride

: 90246-88-1
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate oxime

: 90246-99-4
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

Guidance literature:: at 90 ℃; for 1h;
DOI:10.1021/jm00374a014

Reference yield:

: 7051-15-2
2-chlororesorcinol dimethyl ether

: 90246-99-4
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

Guidance literature:: Multi-step reaction with 9 steps

1: 79 percent / TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

2: 74 percent / BBr₃ / CH₂Cl₂ / 1 h / 0 °C

3: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

4: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

5: LiCl, Me₂SO, H₂O / 2 h / Heating

6: H₂SO₄ / Ambient temperature

7: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

8: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

9: 58 percent / 1 h / 90 °C

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; boron tribromide; titanium tetrachloride; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In dichloromethane; acetic acid; 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00374a014

Reference yield:

: 72482-15-6
3-chloro-2-hydroxy-4-methoxybenzaldehyde

: 90246-99-4
ethyl (E)-7-chloro-2,3-dihydro-5-(o-fluorobenzoyl)-6-hydroxybenzofuran-2-carboxylate O-acetyloxime

Guidance literature:: Multi-step reaction with 7 steps

1: 79.6 percent / K₂CO₃ / butan-2-one / 4.5 h / Heating

2: 82.9 percent / H₂, conc.H₂SO₄ / 20percent Pd/C / acetic acid / 2 h / 2280 Torr

3: LiCl, Me₂SO, H₂O / 2 h / Heating

4: H₂SO₄ / Ambient temperature

5: 69.2 percent / AlCl₃ / 1,2-dichloro-ethane / 3.75 h / 5 - 20 °C

6: 20 percent / NH₂OH*HCl, pyridine / 4 h / Heating

7: 58 percent / 1 h / 90 °C

With pyridine; aluminium trichloride; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; potassium carbonate; dimethyl sulfoxide; lithium chloride; palladium on activated charcoal; In acetic acid; 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00374a014