(S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate
CAS No.:1393378-02-3
Molecular Formula:C₂₀H₂₅N₃O₂
Molecular Weight:339.437
Hs Code.:

Synonyms:(S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

There total 4 articles about (S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1393378-00-1
(S)-2-((pyridin-2-ylmethylamino)methyl)-1-N-Cbz-pyrrolidine

: 1393378-02-3
(S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

Guidance literature:: With formic acid; In water; for 12h; Inert atmosphere; Reflux;
DOI:10.1016/j.jorganchem.2012.03.034

Reference yield:

: 119020-03-0,141774-68-7
2-(S)-aminomethyl-pyrrolidine-1-carboxylic acid benzyl ester

: 1393378-02-3
(S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium sulfate / methanol / 24 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / 12 h / 20 °C / Inert atmosphere

3: formic acid / water / 12 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; formic acid; sodium sulfate; In methanol; water; 3: Eschweiler-Clarke methylation;
DOI:10.1016/j.jorganchem.2012.03.034

Reference yield:

: 1121-60-4
pyridine-2-carbaldehyde

: 1393378-02-3
(S)-benzyl 2-((methyl(pyridin-2-ylmethyl)amino)methyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium sulfate / methanol / 24 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / 12 h / 20 °C / Inert atmosphere

3: formic acid / water / 12 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; formic acid; sodium sulfate; In methanol; water; 3: Eschweiler-Clarke methylation;
DOI:10.1016/j.jorganchem.2012.03.034