N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

Base Information

Chemical Name:N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine
CAS No.:1570255-76-3
Molecular Formula:C₂₂H₂₂F₃N₅O₂S
Molecular Weight:477.51
Hs Code.:

Synonyms:N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

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Chemical Property of N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

Chemical Property:

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Technology Process of N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

There total 5 articles about N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1570262-31-5
5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-amine

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1570255-76-3
N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 100 ℃; for 14h;

Reference yield:

: 3819-88-3
1-fluoro-3-iodo-5-nitrobenzene

: 1570255-76-3
N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide / 1 h / 130 °C / Microwave irradiation

2: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 2 h / 100 °C / Sealed tube

3: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 1.5 h

4: toluene-4-sulfonic acid / 1,4-dioxane / 14 h / 100 °C

With palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 1570255-76-3
N-{5-[4-(methylsulfonyl)piperazin-1-yl]biphenyl-3-yl}-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide / 1 h / 130 °C / Microwave irradiation

2: sodium carbonate; palladium diacetate; tris-(o-tolyl)phosphine / 1,2-dimethoxyethane; water / 2 h / 100 °C / Sealed tube

3: palladium 10% on activated carbon; hydrogen; acetic acid / ethyl acetate / 1.5 h

4: toluene-4-sulfonic acid / 1,4-dioxane / 14 h / 100 °C

With palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; tris-(o-tolyl)phosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; ethyl acetate;