Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Base Information

Chemical Name:Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate
CAS No.:112561-43-0
Molecular Formula:C₂₂H₂₈N₂O₆S
Molecular Weight:448.54
Hs Code.:

Synonyms:Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Suppliers and Price of Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

There total 3 articles about Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 112561-42-9
4-<1-<(4-Methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutyric acid

: 33099-10-4
Methyl N-methyl-L-valinate hydrobromide

: 112561-43-0
Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; 1) -20 deg C, 10 min, 2) -20 deg C, 10 min, then room temp., 45 min.;
DOI:10.1016/S0040-4039(00)96097-0

Reference yield:

: 17639-64-4
N-p-toluenesulfonylpyrrole

: 112561-43-0
Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / BF₃*Et₂O / 1,2-dichloro-ethane / 50 h / Ambient temperature

2: 95 percent / 2.5percent KOH / tetrahydrofuran; H₂O / 3 h / Ambient temperature

3: 87 percent / 1) ClCOOEt, NEt₃ / tetrahydrofuran / 1) -20 deg C, 10 min, 2) -20 deg C, 10 min, then room temp., 45 min.

With potassium hydroxide; chloroformic acid ethyl ester; triethylamine; boron trifluoride diethyl etherate; In tetrahydrofuran; water; 1,2-dichloro-ethane;
DOI:10.1016/S0040-4039(00)96097-0

Reference yield:

: 112561-41-8
Ethyl 4-<1-(4-methylphenylsulfonyl)-2-pyrrolyl>-4-oxobutanoate

: 112561-43-0
Methyl N-methyl-N-<4-<1-<(4-methylphenyl)sulfonyl>-2-pyrrolyl>-4-oxobutanoyl>-L-valinate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 2.5percent KOH / tetrahydrofuran; H₂O / 3 h / Ambient temperature

2: 87 percent / 1) ClCOOEt, NEt₃ / tetrahydrofuran / 1) -20 deg C, 10 min, 2) -20 deg C, 10 min, then room temp., 45 min.

With potassium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(00)96097-0