1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane

Base Information

• Chemical Name: 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane
• CAS No.: 312609-92-0
• Molecular Formula: C₃₁H₄₂O₄SSi
• Molecular Weight: 538.824
• Mol file: 312609-92-0.mol

Synonyms:1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane

Chemical Property of 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane

There total 3 articles about 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tert-butylchlorodiphenylsilane (58479-61-1) + 8-(p-methylbenzenesulfonyloxy)-1-octanol (103010-10-2) → 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane (312609-92-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

DOI:10.1055/s-2000-7614

Reference yield:

1,8-Octanediol (629-41-4) → 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane (312609-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridine / CHCl₃ / 0 °C

2: 93 percent / imidazole / dimethylformamide / 0.5 h / 25 °C

With pyridine; 1H-imidazole; In chloroform; N,N-dimethyl-formamide; 1: Tosylation / 2: Substitution;

DOI:10.1055/s-2000-7614

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 1-((1,1-Dimethylethyl)diphenylsilyloxy)-8-(4-methylphenylsulfonyloxy)octane (312609-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / pyridine / CHCl₃ / 0 °C

2: 93 percent / imidazole / dimethylformamide / 0.5 h / 25 °C

With pyridine; 1H-imidazole; In chloroform; N,N-dimethyl-formamide; 1: Tosylation / 2: Substitution;

DOI:10.1055/s-2000-7614

upstream raw materials:

tert-butylchlorodiphenylsilane

8-(p-methylbenzenesulfonyloxy)-1-octanol

1,8-Octanediol

p-toluenesulfonyl chloride

Downstream raw materials:

8-((1,1-Dimethylethyl)diphenylsilyloxy)octan-1-ol