(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

Base Information

Chemical Name:(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione
CAS No.:89551-54-2
Molecular Formula:C₅₁H₆₄N₂O₆Si₂
Molecular Weight:857.25
Hs Code.:

(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

Synonyms:(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

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Chemical Property of (3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

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Technology Process of (3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

There total 5 articles about (3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 90352-00-4
(3S,6S)-1,4-Dibenzyl-3,6-bis-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-piperazine-2,5-dione

: 89551-54-2
(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

Guidance literature:: With pyridine; hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃;
DOI:10.1016/S0040-4039(00)94158-3

Reference yield:

: 89291-89-4
(E)-4-(tert-Butyl-diphenyl-silanyloxy)-but-2-enoic acid methyl ester

: 89551-54-2
(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -110 deg C, 2.) -78 deg C

2: LiAlH₄ / tetrahydrofuran / -78 °C

3: NaBH₄ / methanol

4: imidazole

5: 88 percent / H₂, pyridine / 20 percent Pd-C / ethanol / 40 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0040-4039(00)94158-3

Reference yield:

: 89291-90-7
4-(tert-Butyl-diphenyl-silanyloxy)-3-((2S,5S)-1,4-dibenzyl-2,5-bis-benzyloxy-3,6-dioxo-piperazin-2-yl)-butyric acid methyl ester

: 89551-54-2
(3S,6S)-1,4-Dibenzyl-3-benzyloxy-3-[3-(tert-butyl-dimethyl-silanyloxy)-1-(tert-butyl-diphenyl-silanyloxymethyl)-propyl]-6-hydroxy-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / -78 °C

2: NaBH₄ / methanol

3: imidazole

4: 88 percent / H₂, pyridine / 20 percent Pd-C / ethanol / 40 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0040-4039(00)94158-3