(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

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Chemical Name:(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one
CAS No.:1404166-77-3
Molecular Formula:C₃₁H₂₈FN₅O₂
Molecular Weight:521.594
Hs Code.:

Synonyms:(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

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Chemical Property of (R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

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Technology Process of (R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

There total 14 articles about (R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

: 1404166-69-3
(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

: 1404166-77-3
(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

Guidance literature:: With pyridine; methanesulfonyl chloride; In acetonitrile; at 22 - 60 ℃; for 5h; Reagent/catalyst; Large scale;
DOI:10.1021/op300237b

Reference yield:

: 1394849-30-9
(R)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

: 1404166-77-3
(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / ethanol / 1 h / -5 - 25 °C / Large scale

2: hydrazine hydrate / 16 h / -3 - 40 °C / Large scale

3: acetic acid / ethanol / 72 h / 60 °C

4: pyridine; methanesulfonyl chloride / acetonitrile / 5 h / 22 - 60 °C / Large scale

With pyridine; hydrazine hydrate; acetic acid; methanesulfonyl chloride; triethylamine; In ethanol; acetonitrile;
DOI:10.1021/op300237b

Reference yield:

: C₁₈H₂₁NO₃S

: 1404166-77-3
(R)-6-{6-[(benzyloxy)methyl]-2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / 16 h / -3 - 40 °C / Large scale

2: pyridinium p-toluenesulfonate / ethanol / 24 h / 40 °C

3: pyridine; methanesulfonyl chloride / acetonitrile / 5 h / 22 - 60 °C / Large scale

With pyridine; pyridinium p-toluenesulfonate; hydrazine hydrate; methanesulfonyl chloride; In ethanol; acetonitrile;
DOI:10.1021/op300237b