(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

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Chemical Name:(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one
CAS No.:1404166-69-3
Molecular Formula:C₃₁H₃₀FN₅O₃
Molecular Weight:539.609
Hs Code.:

Synonyms:(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

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Chemical Property of (R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

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Technology Process of (R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

There total 39 articles about (R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882974-29-0
(RS)-6-[1-bromo-2-(4-fluorophenyl)-2-oxoethyl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one

: 1404169-37-4
(R)-4-[3-(benzyloxy)-2-(hydroxymethyl)propyl]thiosemicarbazide

: 1404166-69-3
(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

Guidance literature:: With potassium dihydrogenphosphate; In ethanol; water; at 28 - 42 ℃; for 22h; Reagent/catalyst; Large scale;
DOI:10.1021/op300237b

Reference yield:

: 1394849-30-9
(R)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

: 1404166-69-3
(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 1 h / -5 - 25 °C / Large scale

2: hydrazine hydrate / 16 h / -3 - 40 °C / Large scale

3: potassium dihydrogenphosphate / water; ethanol / 22 h / 28 - 42 °C / Large scale

With potassium dihydrogenphosphate; hydrazine hydrate; triethylamine; In ethanol; water;
DOI:10.1021/op300237b

Reference yield:

: 1394849-30-9
(R)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride

: 1404166-69-3
(R)-6-(5-{[3-(benzyloxy)-2-(hydroxymethyl)propyl]-amino}-3-(4-fluorophenyl)-1H-pyrazol-4-yl)-2-(2-tolyl)-2,3-dihydropyridazin-3-one

: 1404166-72-8
C₃₁H₃₀FN₅O₃S

: 1404166-73-9
C₃₁H₃₀FN₅O₃S

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 1 h / -5 - 25 °C / Large scale

2: hydrazine hydrate / 16 h / -3 - 40 °C / Large scale

3: acetic acid / ethanol / 72 h / 60 °C

With hydrazine hydrate; acetic acid; triethylamine; In ethanol;
DOI:10.1021/op300237b