Pheniramine Maleate

Base Information

• Chemical Name: Pheniramine Maleate
• CAS No.: 132-20-7
• Deprecated CAS: 155683-11-7
• Molecular Formula: C16H20N2^.C4H4O4
• Molecular Weight: 356.422
• Hs Code.: 2933399090
• European Community (EC) Number: 205-051-4
• UNII: NYW905655B
• ChEMBL ID: CHEMBL1653
• NCI Thesaurus Code: C29358
• NSC Number: 757270
• RXCUI: 266959
• Wikidata: Q27114744
• Mol file: 132-20-7.mol

Synonyms:Avil;Bimaleate, Pheniramine;Daneral;Histapyridamine;Maleate, Pheniramine;Pheniramine;Pheniramine Bimaleate;Pheniramine Maleate;Propheniramine;Prophenpyridamine

Chemical Property of Pheniramine Maleate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 5.07E-05mmHg at 25°C
• Melting Point: 104-108 °C
• Refractive Index: 1.6800 (estimate)
• Boiling Point: 348.3 °C at 760 mmHg
• Flash Point: 164.5 °C
• PSA: 90.73000
• Density: 1.2233 (rough estimate)
• LogP: 2.87700
• Storage Temp.: 2-8°C
• Solubility.: Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
• Water Solubility.: >=1 g/100 mL at 24 ºC
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 356.17360725
• Heavy Atom Count: 26
• Complexity: 340

Purity/Quality:

99% ^*data from raw suppliers

Pheniramine Maleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
• Recent ClinicalTrials: Efficacy of Nasal Naphazoline Hydrocloride + Pheniramine Maleate + Panthenol Compared With Naphazoline Hydrocloride in the Symptomatic Control of Nasal Congestion and Nasopharyngeal
• Recent EU Clinical Trials: Front-Line Venetoclax and Obinutuzumab combination followed by Venetoclax or Venetoclax and Zanubrutinib combination in patients with residual disease: a minimal residual disease (MRD) tailored treatment for young patients with high risk CLL. A phase II multicenter study (VIS trial)
• Uses: Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria. Antihistaminic;H1 antagonist A H1 histamine receptor antagonist. Used medicinally as an antihistaminic (merck).
• Therapeutic Function: Antihistaminic

Technology Process of Pheniramine Maleate

There total 3 articles about Pheniramine Maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pheniramine (86-21-5) + maleic acid (110-16-7,26099-09-2) → pheniramine maleate (132-20-7)

Guidance literature:

In ethanol; at 20 ℃; Solvent;

Reference yield:

benzyl boronic acid (4463-42-7) → pheniramine maleate (132-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; tetrahydrofuran; water / 3 h / 75 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

3: ethanol / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; potassium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

2-bromo-pyridine (109-04-6) → pheniramine maleate (132-20-7)

Guidance literature:

Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / N,N-dimethyl-formamide; tetrahydrofuran; water / 3 h / 75 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 80 °C

3: ethanol / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; potassium carbonate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

pheniramine

maleic acid

benzyl boronic acid

2-bromo-pyridine

Refernces