3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

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Chemical Name:3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid
CAS No.:1021165-39-8
Molecular Formula:C₂₉H₃₁N₃O₃
Molecular Weight:469.583
Hs Code.:

Synonyms:3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

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Chemical Property of 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

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Technology Process of 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

There total 9 articles about 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1021166-03-9
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

: 1021165-39-8
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

Guidance literature:: 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester; With sodium hydroxide; In methanol; water; at 20 ℃; for 18h;

With hydrogenchloride; In methanol; water; pH=4 - 5;
DOI:10.1021/ml3000512

Reference yield:

: 769-92-6
4-tert-Butylaniline

: 1021165-39-8
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: platinum on carbon; hydrogen / methanol; ethyl acetate / 3 h / 760.05 Torr

3.1: potassium peroxymonosulfate / water; N,N-dimethyl-formamide / 1 h / 20 °C

4.1: sodium hydroxide / methanol; water / 18 h / 20 °C

4.2: pH 4 - 5

With potassium peroxymonosulfate; platinum on carbon; hydrogen; triethylamine; HATU; sodium hydroxide; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml3000512

Reference yield:

: 306297-11-0
N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide

: 1021165-39-8
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: methyllithium; lithium bromide / tetrahydrofuran; diethyl ether / 0.08 h / -78 °C / Inert atmosphere

1.2: 0.08 h / -78 °C / Inert atmosphere

1.3: 0.5 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 18 h / 20 °C

3.1: tetrafluoroboric acid; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 80 °C

4.1: palladium 10% on activated carbon; hydrogen / dichloromethane / 18 h / 760.05 Torr

5.1: potassium peroxymonosulfate / water; N,N-dimethyl-formamide / 1 h / 20 °C

6.1: sodium hydroxide / methanol; water / 18 h / 20 °C

6.2: pH 4 - 5

With potassium peroxymonosulfate; tetrafluoroboric acid; palladium 10% on activated carbon; methyllithium; hydrogen; lithium bromide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml3000512