3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

Base Information

Chemical Name:3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester
CAS No.:1021166-03-9
Molecular Formula:C₃₀H₃₃N₃O₃
Molecular Weight:483.61
Hs Code.:

Synonyms:3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

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Chemical Property of 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

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Technology Process of 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

There total 8 articles about 3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 103235-15-0
3-(4-formyl-3,5-dimethylphenyl)propionic acid methyl ester

: 1021166-24-4
3,4-diamino-N-(4-tert-butylphenyl)benzamide

: 1021166-03-9
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

Guidance literature:: With potassium peroxymonosulfate; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/ml3000512

Reference yield:

: 769-92-6
4-tert-Butylaniline

: 1021166-03-9
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

2: platinum on carbon; hydrogen / methanol; ethyl acetate / 3 h / 760.05 Torr

3: potassium peroxymonosulfate / water; N,N-dimethyl-formamide / 1 h / 20 °C

With potassium peroxymonosulfate; platinum on carbon; hydrogen; triethylamine; HATU; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml3000512

Reference yield:

: 306297-11-0
N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide

: 1021166-03-9
3-{4-[6-(4-tert-butylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-3,5-dimethylphenyl}propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methyllithium; lithium bromide / tetrahydrofuran; diethyl ether / 0.08 h / -78 °C / Inert atmosphere

1.2: 0.08 h / -78 °C / Inert atmosphere

1.3: 0.5 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol; water / 18 h / 20 °C

3.1: tetrafluoroboric acid; sodium nitrite / water / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 80 °C

4.1: palladium 10% on activated carbon; hydrogen / dichloromethane / 18 h / 760.05 Torr

5.1: potassium peroxymonosulfate / water; N,N-dimethyl-formamide / 1 h / 20 °C

With potassium peroxymonosulfate; tetrafluoroboric acid; palladium 10% on activated carbon; methyllithium; hydrogen; lithium bromide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml3000512