3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

Base Information

Chemical Name:3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid
CAS No.:1285514-89-7
Molecular Formula:C₂₂H₂₀N₂O₄
Molecular Weight:376.412
Hs Code.:

Synonyms:3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

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Chemical Property of 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

Chemical Property:

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Technology Process of 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

There total 8 articles about 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285514-88-6
ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

: 1285514-89-7
3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-89-7
3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

3.1: hydrogen / palladium on carbon / methanol / 5 h

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h

5.1: water; lithium hydroxide / tetrahydrofuran

With water; hydrogen; potassium hexamethylsilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium on carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285514-89-7
3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h

2.1: water; lithium hydroxide / tetrahydrofuran; methanol

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

4.2: -78 - 20 °C

5.1: hydrogen / palladium on carbon / methanol / 5 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h

7.1: water; lithium hydroxide / tetrahydrofuran

With water; hydrogen; potassium hexamethylsilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium on carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;