ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

Base Information

Chemical Name:ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate
CAS No.:1285514-88-6
Molecular Formula:C₂₄H₂₄N₂O₄
Molecular Weight:404.466
Hs Code.:

Synonyms:ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

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Chemical Property of ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

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Technology Process of ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

There total 7 articles about ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1285517-19-2
ethyl 3-{4-hydroxy-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

: 100-39-0
benzyl bromide

: 1285514-88-6
ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1285514-88-6
ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

2.2: -78 - 20 °C

3.1: hydrogen / palladium on carbon / methanol / 5 h

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h

With hydrogen; potassium hexamethylsilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium on carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 616-76-2
2-hydroxy-5-formylbenzoic acid

: 1285514-88-6
ethyl 3-{4-[(phenylmethyl)oxy]-3-[(3-pyridinylamino)carbonyl]phenyl}propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 24 h

2.1: water; lithium hydroxide / tetrahydrofuran; methanol

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.25 h / -78 °C

4.2: -78 - 20 °C

5.1: hydrogen / palladium on carbon / methanol / 5 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 1 h

With water; hydrogen; potassium hexamethylsilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; palladium on carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;