(Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate

Base Information

• Chemical Name: (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate
• CAS No.: 164254-22-2
• Molecular Formula: C₁₃H₁₃N₃O₄
• Molecular Weight: 275.264
• Mol file: 164254-22-2.mol

Synonyms:(Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate

Chemical Property of (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate

There total 4 articles about (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-methoxylamine hydrochloride (593-56-6) + Ethyl 2-diazo-3-(2-formylphenyl)-3-oxopropionate (164254-15-3) → (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate (164254-22-2) + (E)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate (164254-21-1)

Guidance literature:

With potassium sulfate; magnesium sulfate; In diethyl ether; at 25 ℃; for 40h;

DOI:10.1021/jo00097a042

Reference yield:

2-(dimethoxymethyl)benzaldehyde (132233-84-2) → (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate (164254-22-2)

Guidance literature:

Multi-step reaction with 4 steps

1: LDA / tetrahydrofuran; hexane / 2 h / -78 °C

2: BaMnO₄ / CH₂Cl₂ / 44 h / Heating

3: 10percent aq. HCl, silica gel / CH₂Cl₂ / 3 h / Ambient temperature

4: 16 percent / MgSO₄, K₂SO₄ / diethyl ether / 40 h / 25 °C

With hydrogenchloride; potassium sulfate; barium permanganate; silica gel; magnesium sulfate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

DOI:10.1021/jo00097a042

Reference yield:

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate (164254-39-1) → (Z)-Ethyl 2-diazo-3-oxo-3-<2-((methoxyimino)methyl)phenyl>propionate (164254-22-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent aq. HCl, silica gel / CH₂Cl₂ / 3 h / Ambient temperature

2: 16 percent / MgSO₄, K₂SO₄ / diethyl ether / 40 h / 25 °C

With hydrogenchloride; potassium sulfate; silica gel; magnesium sulfate; In diethyl ether; dichloromethane;

DOI:10.1021/jo00097a042

upstream raw materials:

N-methoxylamine hydrochloride

Ethyl 2-diazo-3-(2-formylphenyl)-3-oxopropionate

2-(dimethoxymethyl)benzaldehyde

Ethyl 2-diazo-3-(2-(dimethoxymethyl)phenyl)-3-oxopropionate