2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

Base Information

Chemical Name:2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid
CAS No.:681253-74-7
Molecular Formula:C₃₅H₃₈N₄O₆
Molecular Weight:610.71
Hs Code.:

2-({2-[2-<i>tert</i>-butoxycarbonylamino-3-(1<i>H</i>-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

Synonyms:2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

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Chemical Property of 2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

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Technology Process of 2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

There total 6 articles about 2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 500213-44-5
2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid methyl ester

: 681253-74-7
2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

Guidance literature:: With barium dihydroxide; In methanol;
DOI:10.1016/j.tetlet.2004.01.048

Reference yield:

: 78879-20-6,144069-68-1,115962-35-1
D-N-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinolinoline-3-carboxylic acid

: 681253-74-7
2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium BF₄; ethyldiisopropylamine / CH₂Cl₂ / 20 °C

2: 100 percent / trifluoroacetic acid / CH₂Cl₂; methoxybenzene

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium BF₄; ethyldiisopropylamine / CH₂Cl₂

4: LiOH / methanol

With lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; methoxybenzene;
DOI:10.1016/j.bmc.2006.03.028

Reference yield:

: 500213-40-1
3-(1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 681253-74-7
2-({2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / trifluoroacetic acid / CH₂Cl₂; methoxybenzene

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium BF₄; ethyldiisopropylamine / CH₂Cl₂

3: LiOH / methanol

With lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; methoxybenzene;
DOI:10.1016/j.bmc.2006.03.028