2,4-Quinolinediol

Base Information

• Chemical Name: 2,4-Quinolinediol
• CAS No.: 86-95-3
• Molecular Formula: C₉H₇NO₂
• Molecular Weight: 161.16
• Hs Code.: 29334900
• Mol file: 86-95-3.mol

Synonyms:2,4-Quinolinediol(7CI);Carbostyril, 4-hydroxy- (6CI,8CI);2,4-Dihydroxyquinoline;4-Hydroxy-1,2-dihydro-2-quinolinone;4-Hydroxy-1H-quinolin-2-one;4-Hydroxy-2-quinolinone;4-Hydroxy-2-quinolone;4-Hydroxycarbostyril;4-Hydroxyquinolin-2(1H)-one;4-Hydroxyquinoline-2(1H)-one;NSC 12465;NSC 13962;

Chemical Property of 2,4-Quinolinediol

Chemical Property:

• Appearance/Colour: very light brown powder
• Melting Point: >300 °C(lit.)
• Refractive Index: 1.5050 (estimate)
• Boiling Point: 303.8 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 137.5 °C
• PSA: 53.09000
• Density: 1.376 g/cm³
• LogP: 1.23370
• Storage Temp.: Room temperature.
• Water Solubility.: Insoluble in water

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dihydroxyquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Quinolinediol

There total 68 articles about 2,4-Quinolinediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate (40059-53-8) → 4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3)

Guidance literature:

ethyl 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate; With water; potassium hydroxide; Reflux;

In water; Acidic conditions;

DOI:10.1021/jo9011915

Reference yield: 99.1%

1H-4-hydroxy-2-oxoquinoline-3-carboxylic acid methyl ester (73776-19-9) → 4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3)

Guidance literature:

With potassium hydroxide; In water; for 15h; Heating;

Reference yield: 99.0%

malonanilic acid (15580-32-2) → 4-Hydroxy-2-quinolone (70254-43-2,70254-44-3,86-95-3)

Guidance literature:

With aluminum (III) chloride; Eaton′s reagent; at 90 ℃; for 6h; Reagent/catalyst; Mechanism; Inert atmosphere;

upstream raw materials:

quinoline

1H-indene-1,3(2H)-dione

ethyl N-acetylanthranilate

3-benzyl-quinoline-2,4-diol

Downstream raw materials:

4-hydroxy-3-phenyl-6H-pyrano[3,2-c]quinoline-2,5-dione

2-methyl-3-phenyl-5H-furo[3,2-c]quinolin-4-one

4-hydroxy-3-(phenylthio)quinolin-2(1H)-one

4-amino-quinolin-2-ol