40059-53-8

Basic information

• Product Name: 1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER
• Synonyms: AURORA KA-4464;1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER;3-Ethoxycarbonyl-2,4-dihydroxyquinoline;4-HYDROXY-2-OXO-1,2-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylicaciethylester;3-carbethoxy-4-hydroxy-2-quinolone;3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-2-oxo-, ethyl ester;Ethyl 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylate
• CAS NO: 40059-53-8
• Molecular Formula: C₁₂H₁₁NO₄
• Molecular Weight: 233.22
• Mol File: 40059-53-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 208 °C
• Boiling Point: 457.986 °C at 760 mmHg
• Flash Point: 230.782 °C
• Appearance: /
• Density: 1.363 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: 1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER(40059-53-8)
• EPA Substance Registry System: 1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER(40059-53-8)

Safety Data

• Hazardous Substances Data: 40059-53-8(Hazardous Substances Data)

Usage

General Description

1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylic acid ethyl ester is a chemical compound with the molecular formula C13H11NO4. It is an ethyl ester derivative of quinolinecarboxylic acid, and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is a yellow crystalline solid that is soluble in organic solvents. 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxylic acid ethyl ester has potential biological and pharmacological activities, as it has been studied for its anti-inflammatory, antioxidant, and antimicrobial properties. Additionally, it is also used as a building block in the production of various medicinal drugs and agrochemicals.

InChI:InChI=1/C12H11NO4/c1-2-17-12(16)9-10(14)7-5-3-4-6-8(7)13-11(9)15/h3-6H,2H2,1H3,(H2,13,14,15)

Upstream product

• 118-48-9 isatoic anhydride 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 551-93-9 2-aminoacetophenone 
• 105-58-8 Diethyl carbonate 
• 110-83-8 cyclohexene 
• 75-03-6 ethyl iodide 
• 169216-62-0 2-oxo-3-ethoxycarbonyl-4-acetoxyquinoline 
• 523-64-8 flindersine 

Downstream Products

• 26906-40-1 ethyl 2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylate 
• 331963-57-6 C₁₈H₁₅N₃O₄ 
• 305862-77-5 C₁₇H₁₂BrN₃O₄ 
• 70254-43-2 4-Hydroxy-2-quinolone 
• 1601219-55-9 N-(1-benzylpiperidin-4-yl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide 
• 1601219-56-0 N-((1-benzylpiperidin-4-yl)methyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamide 
• 331963-26-9 N'-dodecanoyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide 
• 1429014-28-7 N',1-dibenzyl-N'-dodecanoyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide 
• 1186245-14-6 N-[1-(2-Hydroxyethyl)piperidin-4-yl]-3-methoxy-5-(4-methoxybenzyl)-1-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide 
• 1186290-35-6 3-methoxy-5-(4-methoxybenzyl)-1-methyl-4-oxo-N-piperidin-4-yl-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide hydrochloride 
• 1186289-24-6 tert-butyl 4-({[3-methoxy-5-(4-methoxybenzyl)-1-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]quinolin-2-yl]carbonyl}amino)piperidine-1-carboxylate 
• 1186191-38-7 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-piperidin-4-yl-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide 
• 1186191-31-0 3-methoxy-1-methyl-N-(2-morpholin-4-ylethyl)-4-oxo-5-(2-oxo-2-phenylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide 
• 1186191-30-9 3-methoxy-1-methyl-4-oxo-5-(2-oxo-2-phenylethyl)-N-(2-piperidin-1-ylethyl)-4,5-dihydro-1H-pyrrolo[3,2-c]quinoline-2-carboxamide 

Relevant articles and documents

The laccase-catalyzed domino reaction between catechols and heterocyclic 1,3-dicarbonyls and theunambiguous structure elucidation of the products by NMR spectroscopy and X-ray crystal structure analysis

(Chemical Equation Presented) The laccase-catalyzed reaction between catechols and heterocyclic 1,3-dicarbonyls (pyridinones, quinolinones, thiocoumarins) using aerial oxygen as the oxidant delivers benzofuropyridinones, benzofuroquinolinones, and thiocou

Alkylidenephosphoranes in heterocyclic synthesis: Reactivity of benzoxazinones with resonance-stabilized phosphorus ylides

2H-3,1-Benzoxazine-2,4(1H)-dione and its N-methyl analogue react with alkylidenephosphoranes to give substituted quinolines and benzazepines as well as indanone and furan derivatives. Reaction mechanisms to explain the formation of products obtained are outlined. Georg Thieme Verlag Stuttgart.